File:Mechanisms Involved in Lead toxicity in the Central Nervous System (CNS).webp
Mechanisms_Involved_in_Lead_toxicity_in_the_Central_Nervous_System_(CNS).webp (550 × 328 pixels, file size: 35 KB, MIME type: image/webp)
Summary
Description | English: Once Pb enters the CNS, it binds to voltage-gated calcium channels and decreases the transportation of calcium ions. Lead interacts with Ca2+ binding sites, which eventually decreases the activation of post-synaptic receptors. Lead forms Pb-NMDA complexes, which alters the intracellular levels of Ca2+ in the postsynaptic neuron. In the end, Pb alters the redox environment, promoting cell death. |
Date | 28 January 2021 |
File source | https://www.mdpi.com/2305-6304/9/2/23 |
Author | Daniela Ramírez Ortega 1ORCID,Dinora F. González Esquivel 1ORCID,Tonali Blanco Ayala 1ORCID,Benjamín Pineda 2ORCID,Saul Gómez Manzo 3ORCID,Jaime Marcial Quino 4ORCID,Paul Carrillo Mora 5ORCID andVerónica Pérez de la Cruz 1,*ORCID |
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current | 02:59, 22 June 2024 | ![]() | 550 × 328 (35 KB) | AsthaChowdhury (talk | contribs) | Uploaded a work by Daniela Ramírez Ortega 1ORCID,Dinora F. González Esquivel 1ORCID,Tonali Blanco Ayala 1ORCID,Benjamín Pineda 2ORCID,Saul Gómez Manzo 3ORCID,Jaime Marcial Quino 4ORCID,Paul Carrillo Mora 5ORCID andVerónica Pérez de la Cruz 1,*ORCID from https://www.mdpi.com/2305-6304/9/2/23 with UploadWizard |
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