Course:PHAR451/Hyperthyroidism
Thyroid Therapeutics | |
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PHAR 451 | |
Section: | |
Instructor: | Dr. Peter Loewen |
Email: | peter.loewen@ubc.ca |
Office: | PHRM 6624 |
Office Hours: | |
Class Schedule: | |
Classroom: | |
Important Course Pages | |
Syllabus | |
Lecture Notes | |
Assignments | |
Course Discussion | |
Pre-session Objectives
- Be able to describe the physiology of thyroid function.
- Be able to explain the biochemical parameters used to evaluate thyroid function.
- Be able to describe the pathophysiology of the most common causes of hyper- and hypothyroidism.
- Be able to name the signs and symptoms of hyper- and hypo-thyroidism.
Session Objectives
By the end of the the session and upon further study and reflection, students should be able to
- rationalize a diagnosis of hyperthyroidism on the basis of signs and symptoms combined with lab tests.
- design, implement and monitor (efficacy/toxicity) an effective pharmacotherapeutic plan for managing Graves’ Disease.
Pre-session Assignment
- Obtain Peter Loewen's Thyroid Physiology, Pharmacology, & Pharmacotherapy PLOP.
- Read Brent GA. Graves’ Disease. N Engl J Med 2008;358:2594-605.
- Complete the self-assessment questions below
- Obtain and review the session slides, posted in Connect.
Preparatory self-assessment questions
1. The predominant hormone secreted by the thyroid gland is
- a. Triiodothyronine
- b. Tetraiodothyronine
- c. Liothyronine
- d. Parathyroid hormone
2. The metabolically active thyroid hormone, (________), is produced mainly (_________)
- a. T3, in peripheral tissues
- b. T4, in peripheral tissues
- c. T3, in the thyroid
- d. T4, in the thyroid
3. The most common cause of hypothyroidism in North America is
- a. Iodine deficiency
- b. Graves’ disease
- c. Amiodarone
- d. Autoimmune thyroiditis
4. The most common cause of hyperthyroidism in North America is
- a. Iodine excess
- b. Graves’ disease
- c. Autoimmune thyroiditis
- d. Toxic multinodular goitre
5. Which constellation of symptoms is most consistent with hyperthyroidism
- a. Depression, constipation, ascites, bradycardia
- b. Normocytic anemia, pleural effusion, menorrhagia, myalgia
- c. Bradyphasia, eczema, proptosis, paresthesia
- d. Thinning of hair, amenorrhea, osteoporosis, muscle weakness
References & Additional Reading
- ASCE / ATA Clinical Practice Guidelines for Hypothyroidism in Adults Endocrine Practice 2012;18(6):989-1027.
- Nygaard B. Hyperthyroidism in Pregnancy. ClinicalEvidence 2010;07:611.
- Bruere H, Fauchier L, Bernard Brunet A, et al. History of Thyroid Disorders in Relation to Clinical Outcomes in Atrial Fibrillation. Am J Med. 2015;128(1):30-37.
- Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med. 2012;172(10):799-809
- Chiha M, Samarasinghe S, Kabaker AS. Thyroid Storm: An Updated Review. J Intensive Care Med 2013;
- Brent GA. Graves’ Disease. N Engl J Med 2008;358:2594-605.