File:Mechanism of action of Shiga Toxin (Stx).jpg
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Summary
| Description | English: Stx is constituted by a pentamer of B subunits bound to a catalytic A subunit. The B subunits bind to globotriaosylceramide (Gb3) expressed by some eukaryotic cells (1) Stx is internalized by endocytosis (2) Subsequently, Stx undergoes retrograde transport to the trans-Golgi network (TGN) (3) and then to the endoplasmic reticulum (ER) (4) In the ER, Stx encounters its target, the ribosome, inactivating it (4) As a consquence, Stx inhibits protein synthesis, causing cell death by apoptosis. |
| Date | 7 June 2012 |
| File source | https://www.researchgate.net/figure/Mechanism-of-action-of-Shiga-toxin-Stx-Stx-is-constituted-by-a-pentamer-of-B-subunits_fig1_230736311 |
| Author | Alline Roberta Pacheco, Vanessa Sperandio |
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| current | 05:56, 19 March 2022 | | 1,360 × 852 (118 KB) | AndyJia (talk | contribs) | Uploaded a work by Alline Roberta Pacheco, Vanessa Sperandio from https://www.researchgate.net/figure/Mechanism-of-action-of-Shiga-toxin-Stx-Stx-is-constituted-by-a-pentamer-of-B-subunits_fig1_230736311 with UploadWizard |
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