Nuclei and chromatin

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Biological membranes
Unit 3 BIOL 200
Welcome to the tutoring wiki for BIOL 200. Here is where you'll find learning objectives and summary for Unit 3 of BIOL 200
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Interphase Nucleus[edit | edit source]

Describe the structure and organization of the components of the interphase nucleus, and recognize these structures in TEM micrographs.[edit | edit source]

Explain how proteins are transported into and out of the nucleus, including the roles of the nuclear localization/export signal, the importin/exportin receptors of the NLS, and the nuclear pore complex.[edit | edit source]

Interpret experiments that show how nuclear localization signals may be necessary and sufficient for nuclear import.[edit | edit source]

Nucleic Acids Review[edit | edit source]

Recognize the structures of nucleotides, purines, pyrimidines, ribose, deoxyribose.[edit | edit source]

Distinguish the 3' and 5' ends of a DNA molecule.[edit | edit source]

Explain the role of hydrogen bonds in generating secondary structure of RNA.[edit | edit source]

Chromatin and Chromosomes[edit | edit source]

Analytically describe chromatin structure. Explain how proteins and DNA interact to form chromosomes, starting with the 2nm naked DNA molecule.[edit | edit source]

Discuss primary, secondary, tertiary, quaternary levels of protein structure in the context of chromatin structure.[edit | edit source]

Explain the structure of nucleosomes and the forces stabilizing these structures.[edit | edit source]

Explain further condensation of the chromatin structure, including the 11 nm fibre, higher order structures, chromosomal loops, euchromatin and heterochromatin.[edit | edit source]

Diagram the major parts of chromosomes including the centromere and telomere.[edit | edit source]

Explain and interpret experiments providing quantitative information about the spacing of nucleosomes and the amount of DNA associated with these structures.[edit | edit source]